Marbella reads: For you, Intestinal bacteria and depression
According to a study published in Nature Microbiology, the microbes that inhabit our intestines seem to have some influence on our mental health.
Although it may be surprising, depression may have a lot to do with intestinal bacteria. This has been seen by the first population-based study on the link between intestinal bacteria and mental health that has identified specific intestinal bacteria related to depression. The work, published by Nature Microbiology, provides evidence that a wide range of intestinal bacteria can produce neuroactive compounds.
The team from the University of Leuven coordinated by Jeroen Raes studied the relationship between intestinal bacteria and quality of life and depression. For this, the Belgian researchers combined fecal microbiome data with diagnoses of depression of 1,054 individuals enrolled in the The Flemish Gut Flora Project and identified specific groups of microorganisms that correlated positively or negatively with mental health.
Specifically, they found that two bacterial genera, Coprococcus and Dialister, had almost disappeared in people with depression, regardless of the antidepressant treatment they were receiving.
The results were validated in an independent cohort of 1,063 and in another of patients diagnosed with clinical depression in the university hospitals of Leuven.
The relationship between intestinal microbial metabolism and mental health is a controversial issue in microbiome research, Raes acknowledges. "The idea that microbial metabolites can interact with our brain and, therefore, behavior and feelings, is intriguing, but the communication between microbiome and intestinal brain has been explored mainly in animal models and very little in humans." Now, in this work at the population level "we have identified several groups of bacteria that varied with human depression and quality of life in all populations."
The team of Raes and had located in a previous study a constellation or enterotype of microbial community characterized by a low prevalence of microbial counts among patients with Crohn's disease. In the current one, they surprisingly found that a similar type of community was related to depression and reduced quality of life.
The team from the University of Leuven coordinated by Jeroen Raes studied the relationship between intestinal bacteria and quality of life and depression. For this, the Belgian researchers combined fecal microbiome data with diagnoses of depression of 1,054 individuals enrolled in the The Flemish Gut Flora Project and identified specific groups of microorganisms that correlated positively or negatively with mental health.
Specifically, they found that two bacterial genera, Coprococcus and Dialister, had almost disappeared in people with depression, regardless of the antidepressant treatment they were receiving.
The results were validated in an independent cohort of 1,063 and in another of patients diagnosed with clinical depression in the university hospitals of Leuven.
The relationship between intestinal microbial metabolism and mental health is a controversial issue in microbiome research, Raes acknowledges. "The idea that microbial metabolites can interact with our brain and, therefore, behavior and feelings, is intriguing, but the communication between microbiome and intestinal brain has been explored mainly in animal models and very little in humans." Now, in this work at the population level "we have identified several groups of bacteria that varied with human depression and quality of life in all populations."
The team of Raes and had located in a previous study a constellation or enterotype of microbial community characterized by a low prevalence of microbial counts among patients with Crohn's disease. In the current one, they surprisingly found that a similar type of community was related to depression and reduced quality of life.
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